Burns R A, Milner J A
Carcinogenesis. 1984 Dec;5(12):1539-42. doi: 10.1093/carcin/5.12.1539.
The effects of supplementing a 14% casein diet with 5% L-arginine on rat mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and N-methyl-N-nitrosourea (MNU) were investigated. Dietary arginine supplementation had no significant effect on food intake or growth. In rats treated with either DMBA or MNU, tumor incidence was not significantly affected, but the number of new tumors appearing each week and the cumulative tumor weight per rat were significantly decreased in rats fed 5% arginine diets. In vitro experiments indicated that arginine had no effect on the enzymatic conversion of DMBA to electrophilic DNA-binding metabolites. The decreased tumorigenicity of both MNU and DMBA in rats given supplemental arginine suggests that this amino acid has an inhibitory effect on stage(s) of chemical carcinogenesis other than bioactivation of procarcinogens.
研究了在14%酪蛋白饮食中添加5% L-精氨酸对7,12-二甲基苯并[a]蒽（DMBA）和N-甲基-N-亚硝基脲（MNU）诱导的大鼠乳腺肿瘤的影响。膳食补充精氨酸对食物摄入量或生长没有显著影响。在用DMBA或MNU处理的大鼠中，肿瘤发生率没有受到显著影响，但在喂食5%精氨酸饮食的大鼠中，每周出现的新肿瘤数量和每只大鼠的累积肿瘤重量显著降低。体外实验表明，精氨酸对DMBA向亲电子DNA结合代谢物的酶促转化没有影响。补充精氨酸的大鼠中MNU和DMBA的致瘤性降低表明，这种氨基酸对化学致癌过程中除前致癌物生物活化以外的阶段具有抑制作用。
