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N-亚硝基甲基脲诱导的大鼠乳腺肿瘤作为人类乳腺癌模型。

N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer.

作者信息

Gusterson B A, Williams J C

出版信息

J R Soc Med. 1981 Jan;74(1):56-9. doi: 10.1177/014107688107400111.

DOI:10.1177/014107688107400111
PMID:6780689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1438336/
Abstract

A histopathological study is reported of the autopsy finding in two strains of rats treated with N-methyl-N-nitrosourea (MNU). The induced mammary tumours were histologically indistinguishable from those produced by dimethylbenz(a)anthracene (DMBA). A number of other primary tumours were found and there was no evidence of metastases.

摘要

本文报告了对两组经N-甲基-N-亚硝基脲（MNU）处理的大鼠尸检结果的组织病理学研究。诱导产生的乳腺肿瘤在组织学上与由二甲基苯并(a)蒽（DMBA）产生的肿瘤无法区分。还发现了一些其他原发性肿瘤，且无转移迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/1438336/b156cbff8f55/jrsocmed00265-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/1438336/aad75e083880/jrsocmed00265-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/1438336/b156cbff8f55/jrsocmed00265-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/1438336/aad75e083880/jrsocmed00265-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f6b/1438336/b156cbff8f55/jrsocmed00265-0080-b.jpg

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N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer.N-亚硝基甲基脲诱导的大鼠乳腺肿瘤作为人类乳腺癌模型。
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本文引用的文献

1
Development of adenocarcinoma of the breast in the Wistar rat following the gastric instillation of methylcholanthrene.胃内灌注甲基胆蒽后Wistar大鼠乳腺腺癌的发生
J Natl Cancer Inst. 1949 Oct;10(2):255-66.
2
Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.单次喂食多环烃诱导的乳腺癌及其抑制作用。
Nature. 1961 Jan 21;189:204-7. doi: 10.1038/189204a0.
3
Stem cells in rat mammary development and cancer: a review.大鼠乳腺发育与癌症中的干细胞：综述
J R Soc Med. 1980 Jun;73(6):437-42. doi: 10.1177/014107688007300609.
4
N-nitrosomethylurea as mammary gland carcinogen in rats.N-亚硝基甲基脲作为大鼠乳腺致癌物
J Natl Cancer Inst. 1975 Feb;54(2):401-14.