N-亚硝基甲基脲诱导的大鼠乳腺肿瘤作为人类乳腺癌模型。
N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer.
作者信息
Gusterson B A, Williams J C
出版信息
J R Soc Med. 1981 Jan;74(1):56-9. doi: 10.1177/014107688107400111.
Abstract
A histopathological study is reported of the autopsy finding in two strains of rats treated with N-methyl-N-nitrosourea (MNU). The induced mammary tumours were histologically indistinguishable from those produced by dimethylbenz(a)anthracene (DMBA). A number of other primary tumours were found and there was no evidence of metastases.
摘要
本文报告了对两组经N-甲基-N-亚硝基脲（MNU）处理的大鼠尸检结果的组织病理学研究。诱导产生的乳腺肿瘤在组织学上与由二甲基苯并(a)蒽（DMBA）产生的肿瘤无法区分。还发现了一些其他原发性肿瘤，且无转移迹象。
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