Stanhope R, Adams J, Jacobs H S, Brook C G
Arch Dis Child. 1985 Feb;60(2):116-9. doi: 10.1136/adc.60.2.116.
Ultrasound assessment of ovarian volume, follicular size, and uterine growth was undertaken in 40 normal premenarcheal girls aged 6 months to 14 years. Ovarian follicles were detected from 6 months of age and increased in size and number, so that after the age of 8.5 years there was a progressive increase in the incidence of 'megalocystic' appearance. Eight girls with idiopathic precocious puberty had large megalocystic ovaries which regressed on treatment with gonadotrophin releasing hormone analogue. These findings contrasted with those seen in two prepubertal patients with hypogonadotrophic hypogonadism in whom the natural sequence of ovarian development was greatly accelerated by pulsatile administration of native gonadotrophin releasing hormone.
对40名年龄在6个月至14岁的正常青春期前女孩进行了超声检查，评估卵巢体积、卵泡大小和子宫生长情况。6个月大时即可检测到卵巢卵泡，其大小和数量不断增加，因此8.5岁以后，“巨囊性”外观的发生率逐渐上升。8名特发性性早熟女孩有巨大的囊性卵巢，用促性腺激素释放激素类似物治疗后缩小。这些发现与两名青春期前性腺功能减退患者的情况形成对比，在这两名患者中，天然促性腺激素释放激素的脉冲给药极大地加速了卵巢发育的自然进程。
