de Graaf P, Pauwels E K, Vos P H, Schicht I M, te Velde J, de Graeff J
Eur J Nucl Med. 1984;9(9):419-25. doi: 10.1007/BF00295578.
Skeletal radiotracer (99mTc-HEDP) uptake was quantitated with and without the aid of a computer in 30 chronic dialysis patients with histologic evidence of renal osteodystrophy. Before scintigraphy, elevated soft-tissue activity due to the absence of renal radiotracer excretion was reduced by hemodialysis. The results were compared with those of a normal group and with the results of the biochemical and the bone morphometric studies of these patients. In all patients the radiotracer uptake was elevated, often markedly. In several patients with minimal histologic bone disease, however, soft-tissue activity could not be normalized by hemodialysis although its influence on the quantitative data could be further reduced (but not excluded) by computer evaluation of skeletal radiotracer uptake. Since the latter technique clearly distinguished the majority of the patients from the normals, it appears that computerized quantitative skeletal analysis is a potentially accurate scintigraphic method for detecting renal osteodystrophy. The significant relationship between skeletal radiotracer uptake, in particular at the bone biopsy site, and only the histologic features of increased bone turnover suggest that hyperparathyroidism is the major cause of this increased tracer uptake in renal osteodystrophy.
在30例有肾性骨营养不良组织学证据的慢性透析患者中，借助或不借助计算机对骨骼放射性示踪剂（99mTc - HEDP）摄取进行了定量分析。在闪烁扫描前，因肾脏放射性示踪剂排泄缺失导致的软组织活性升高通过血液透析得以降低。将结果与正常组以及这些患者的生化和骨形态计量学研究结果进行了比较。所有患者的放射性示踪剂摄取均升高，且常常显著升高。然而，在一些组织学骨病轻微的患者中，尽管通过计算机评估骨骼放射性示踪剂摄取可进一步降低（但不能排除）其对定量数据的影响，但血液透析无法使软组织活性恢复正常。由于后一种技术能明显区分大多数患者与正常人，因此计算机化定量骨骼分析似乎是检测肾性骨营养不良的一种潜在准确的闪烁扫描方法。骨骼放射性示踪剂摄取，尤其是在骨活检部位，与仅增加骨转换的组织学特征之间的显著关系表明，甲状旁腺功能亢进是肾性骨营养不良中这种示踪剂摄取增加的主要原因。
