Omata Y, Sethi K K, Brandis H
Immunol Lett. 1984;8(3):147-52. doi: 10.1016/0165-2478(84)90068-3.
The present study has demonstrated marked increase in the relative percentage of Ia-positive macrophages among the peritoneal macrophage population(s) of BALB/c mice infected intraperitoneally with Toxoplasma gondii or when chronically infected mice were rechallenged with Toxoplasma. The observed increase in Ia-positive peritoneal macrophage numbers coincided with the appearance of interferon-gamma (IFN-gamma) in the sera of infected mice. The appearance of elevated serum IFN-gamma titer was a temporary event but the increased percentage of Ia-positive macrophages persisted. The data presented have documented that antigen-specific proliferation response of vigorously purified Toxoplasma-sensitized T-cells is dependent upon Ia-bearing macrophages. This model is useful for future studies into various aspects of the interaction(s) between parasite antigens and Ia-antigen(s) at the macrophage surface for successful recognition of antigen-specific T-cells.
本研究表明，在经腹腔感染刚地弓形虫的BALB/c小鼠的腹腔巨噬细胞群体中，或在慢性感染小鼠再次感染弓形虫时，Ia阳性巨噬细胞的相对百分比显著增加。观察到的Ia阳性腹腔巨噬细胞数量的增加与感染小鼠血清中γ干扰素（IFN-γ）的出现相一致。血清IFN-γ滴度升高是一个暂时的现象，但Ia阳性巨噬细胞的百分比增加持续存在。所呈现的数据证明，经过大力纯化的弓形虫致敏T细胞的抗原特异性增殖反应依赖于携带Ia的巨噬细胞。该模型有助于未来研究寄生虫抗原与巨噬细胞表面Ia抗原之间相互作用的各个方面，以成功识别抗原特异性T细胞。
