[磺脲类制剂对患有四氧嘧啶前期糖尿病、潜伏性糖尿病和轻度显性糖尿病的雌性大鼠的妊娠过程及胎儿状态的影响]
[Effect of sulfonylurea preparations on the course of pregnancy and the state of the fetuses of female rats with alloxan prediabetes, latent diabetes and mild forms of manifest diabetes].
作者信息
Onegova R F
出版信息
Probl Endokrinol (Mosk). 1978 Mar-Apr;24(2):67-70.
PMID:643834
Abstract
The influence of antidiabetic sulphanylamides, used before the occurrence of pregnancy, on the weight of fetuses and placentae was revealed in rats with alloxan "prediabetes", latent diabetes, and manifest diabetes. Diabetes compensation before the occurrence of pregnancy in rats with "prediabetes" and latent diabetes by means of chlorpropamide, and in rats with manifest diabetes with chlorpropamide together with biguanides led to a significant reduction of the weight of fetuses and prevented their death.
摘要
在患有四氧嘧啶“前驱糖尿病”、潜伏性糖尿病和显性糖尿病的大鼠中，揭示了妊娠前使用的抗糖尿病磺胺类药物对胎儿和胎盘重量的影响。对于患有“前驱糖尿病”和潜伏性糖尿病的大鼠，在妊娠前通过氯磺丙脲来补偿糖尿病；对于患有显性糖尿病的大鼠，则通过氯磺丙脲与双胍类药物联合使用来补偿糖尿病，这导致胎儿体重显著降低并防止了胎儿死亡。
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