Sokoloverova I M, Onegova R F
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):61-4.
The work was performed on female rats to which alloxan was administered at immature age. Placental permeability was studied in female rats, healthy ones (170 fetuses), with prediabetes (124 fetuses), with latent diabetes (102 fetuses), and with manifest diabetes (112 fetuses). Permeability of placental membrane was assessed by means of the fluorimetric method of determination in the fetal organism of uranin, a stain administered into the blood of a pregnant animal. The results of the investigations demonstrated that in rats with alloxan prediabetes, latent and manifest diabetes permeability of placental membrane showed a significant elevation (P less than 0.001). There was revealed a direct relationship between the extent of the insular insufficiency and permeability of the placental membrane.
该研究以幼年时注射了四氧嘧啶的雌性大鼠为实验对象。对健康雌性大鼠（170只胎儿）、患有糖尿病前期的雌性大鼠（124只胎儿）、患有潜伏性糖尿病的雌性大鼠（102只胎儿）以及患有显性糖尿病的雌性大鼠（112只胎儿）的胎盘通透性进行了研究。通过荧光测定法评估胎盘膜的通透性，该方法是通过测定注入怀孕动物血液中的染料（uranin）在胎儿体内的含量来进行的。研究结果表明，在患有四氧嘧啶诱导的糖尿病前期、潜伏性和显性糖尿病的大鼠中，胎盘膜的通透性显著升高（P小于0.001）。研究发现胰岛功能不全的程度与胎盘膜的通透性之间存在直接关系。
