人类凝血因子VIII基因的特征分析。
Characterization of the human factor VIII gene.
作者信息
Gitschier J, Wood W I, Goralka T M, Wion K L, Chen E Y, Eaton D H, Vehar G A, Capon D J, Lawn R M
出版信息
Nature. 1984;312(5992):326-30. doi: 10.1038/312326a0.
DOI:10.1038/312326a0
PMID:6438525
Abstract
The complete 186,000 base-pair (bp) human factor VIII gene has been isolated and consists of 26 exons ranging in size from 69 to 3,106 bp and introns as large as 32.4 kilobases (kb). Nine kb of mRNA and protein-coding DNA has been sequenced and the mRNA termini have been mapped. The relationship between internal duplications in factor VIII and evolution of the gene is discussed.
摘要
完整的186,000个碱基对（bp）的人凝血因子VIII基因已被分离出来，它由26个外显子组成，大小从69到3106 bp不等，内含子则大至32.4千碱基（kb）。已对9 kb的信使核糖核酸（mRNA）和蛋白质编码DNA进行了测序，并确定了mRNA的末端位置。本文还讨论了凝血因子VIII内部重复序列与该基因进化之间的关系。
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