Carr D H
Physiol Chem Phys Med NMR. 1984;16(2):137-44.
Rapid development of paramagnetic NMR contrast agents has occurred over the past 3 years. Useful agents include chelates of iron and gadolinium. Gadolinium-DTPA was used safely in 23 human subjects with brain tumors, hepatic tumors and cysts, and a variety of abdominal and pelvic tumors. Various patterns of contrast-enhancement were noted. These agents can radically alter NMR image contrast. Optimum doses, pulse sequences and timing of imaging remain to be determined.
在过去三年中，顺磁性核磁共振造影剂得到了迅速发展。有用的造影剂包括铁和钆的螯合物。钆-DTPA已在23名患有脑肿瘤、肝肿瘤和囊肿以及各种腹部和盆腔肿瘤的人类受试者中安全使用。观察到了各种造影增强模式。这些造影剂可从根本上改变核磁共振图像的对比度。最佳剂量、脉冲序列和成像时间仍有待确定。
