6-羟基多巴胺对静息及运动状态下骨骼肌和心肌碳水化合物代谢的影响。

Effects of 6-hydroxydopamine on the carbohydrate metabolism of skeletal and heart muscles in rest and during exercise.

作者信息

Derevenco P, Wittenberger C, Frecus G, Rosioru C, Anghel I

出版信息

Physiologie. 1984 Jul-Sep;21(3):173-9.

Abstract

A mild 10 min exercise, induced by "in vivo" electrical stimulation of the rat gastrocnemius, causes decreases of the muscle glycogen content (G) and phosphorylase alpha activity (PA), and an increase of its overall glycolytic capacity (OGC); in the myocardium, PA decrease of liver glycogen were brought about by peripheral administration of 6-OHDA; these were probably also related to tissue hypoxia. Modifications elicited by exercise in 6-OHDA treated rats (increase of PA, but no modification of G and OGC in GM; decrease of G in the liver; decrease of OGC in M) suggest some impairments of the ability to adapt the tissue metabolism to increased energetic needs.

摘要

通过对大鼠腓肠肌进行“体内”电刺激诱导的10分钟轻度运动，会导致肌肉糖原含量（G）和磷酸化酶α活性（PA）降低，以及整体糖酵解能力（OGC）增加；在心肌中，外周给予6-羟基多巴胺（6-OHDA）会导致肝糖原的PA降低；这些可能也与组织缺氧有关。6-OHDA处理的大鼠运动引起的变化（GM中PA增加，但G和OGC无变化；肝脏中G降低；M中OGC降低）表明组织代谢适应能量需求增加的能力存在一些损害。