Laurian Y, Lambert T, Larrieu M J
Rev Fr Transfus Immunohematol. 1984 Sep;27(4):493-6. doi: 10.1016/s0338-4535(84)80147-6.
The occurrence during the last 2 years of 29 cases of AIDS in hemophiliacs (21 in USA and 8 in Europe) suggests possible transmission of this disease by blood products. All these patients had received Factor VIII or IX concentrates and developed pneumocystis carinii pneumonia or other opportunistic infections. Kaposi's sarcoma was not observed in any patient. Recent studies have focused on the frequency of AIDS-related complex in hemophiliacs, which may arise as a crucial problem. However this does not justify at the moment any reduction in the substitutive treatment of hemophiliac patients unless new clues to the understanding of these disorders are provided. Therefore, it is mostly important to clearly define, through research programs and precise follow-up of patients, blood products which can be used safely in hemophiliacs.
过去两年间，血友病患者中出现了29例艾滋病病例（美国21例，欧洲8例），这表明该疾病可能通过血液制品传播。所有这些患者都接受过凝血因子VIII或IX浓缩剂治疗，并患上了卡氏肺孢子虫肺炎或其他机会性感染。所有患者均未观察到卡波西肉瘤。最近的研究集中在血友病患者中艾滋病相关综合征的发生率上，这可能成为一个关键问题。然而，目前这并不能成为减少血友病患者替代治疗的理由，除非能提供有关这些疾病的新线索。因此，通过研究项目和对患者的精确随访，明确界定可安全用于血友病患者的血液制品至关重要。
