Leng L, Bod'a K, Tasenov K T, Karinbaev R S, Makasev E K, Rachimberdiev S A, Tlegenov D K, Jurgalieva L A
Vet Med (Praha). 1984 Sep;29(9):539-47.
Experiments were performed with young two-humped camels exposed to 36-hour starvation with free access to water. The renal functions were measured by the standard clearance method. In spite of the administration of 20 micrograms DDAVP, a higher urine flow rate was recorded in the camels subjected to control measurements (feed intake) than in the fasting period (1.45 +/- 0.06 vs. 0.96 +/- 0.06 ml . min-1, P less than less than 0.001). On the second day of fasting the camels had a significantly reduced glomerular filtration rate (GFR 317.5 +/- 23.2 vs. 170.2 +/- 17.4 ml . min-1, P less than 0.001), urea output (700.5 +/- 62.9 vs. 352.2 +/- 64.7 mumol . min-1, P less than 0.005), and fractional excretion of urea (26.9 +/- 2.8 vs. 17.9 +/- 1.7%, P less than 0.01), whereas their tubular resorption. of urea (Reab urea/GFR) increased (6.28 +/- 0.61 vs. 9.12 +/- 0.82 mumol . ml-1, P less than 0.02). No significant difference was found in the concentration of urea in plasma in the fed camels and in fasting camels (8.55 +/- 0.64 vs. 11.18 +/- 1.09 mmol . l-1, N. S.). The creatinine inulin clearance ratio (C creat/Cin) was 0.92 +/- 0.07 when the animals were fed and 1.17 +/- 0.05 when the animals starved (P less than 0.001); this suggests that the clearance of endogenous creatinine is not suitable for GFR measurement in camels under different conditions of nutrition. The kidneys of camels regulate the excretion of urea during short-time fasting mainly through the reduction of glomerular filtration rate and just partly through an increased tubular resorption.
对幼年双峰驼进行了实验，使其在可自由饮水的情况下禁食36小时。通过标准清除率方法测量肾功能。尽管给予了20微克去氨加压素，但在进行对照测量（进食量）的骆驼中记录到的尿流率高于禁食期（1.45±0.06对0.96±0.06毫升·分钟⁻¹，P＜＜0.001）。在禁食的第二天，骆驼的肾小球滤过率显著降低（GFR 317.5±23.2对170.2±17.4毫升·分钟⁻¹，P＜0.001），尿素排出量（700.5±62.9对352.2±64.7微摩尔·分钟⁻¹，P＜0.005），以及尿素分数排泄率（26.9±2.8对17.9±1.7%，P＜0.01），而它们的肾小管尿素重吸收（Reab尿素/GFR）增加（6.28±0.61对9.12±0.82微摩尔·毫升⁻¹，P＜0.02）。在进食的骆驼和禁食的骆驼中，血浆尿素浓度未发现显著差异（8.55±0.64对11.18±1.09毫摩尔·升⁻¹，无显著差异）。动物进食时肌酐菊粉清除率比值（C肌酐/C菊粉）为0.92±0.07，饥饿时为1.17±0.05（P＜0.001）；这表明在内源性肌酐清除率在骆驼不同营养状况下不适合用于测量肾小球滤过率。骆驼的肾脏在短期禁食期间主要通过降低肾小球滤过率来调节尿素排泄，仅部分通过增加肾小管重吸收来调节。
