Hainaut J, Dutertre J, Laverdant C
Ann Med Interne (Paris). 1984;135(6):444-8.
Blood samples were taken from 1,279 healthy adults for radioimmunological studies before their collective departure to an endemic area and received an administration of polyvalent immunoglobin for hepatitis A prophylaxis. On the 120th day, 1,220 subjects were in good health and their serum was studied again. Hepatitis A was observed in 59 cases, confirmed either by the presence of virus in the stool or by the demonstration of anti-HAV IgM, when other causes of hepatitis had been excluded. The following results were observed in the two groups: a) Subjects having HAV antibodies with a titre of about 1:100 in the initial blood samples had a reduced risk of hepatitis. Subjects with lower titres and, paradoxically, with higher titres, had a significantly higher risk. b) Markers of HBV were less commonly present in the initial blood samples of subjects who did not develop hepatitis. c) Low titres of HAV antibodies (less than 20) were commonly associated with markers of HBV in the initial samples of subjects who developed hepatitis. This suggests either a congenital susceptibility to infection to both viruses or that prior HBV infection increases the risk of HAV infection.
在1279名健康成年人集体前往疫区之前，采集他们的血样用于放射免疫研究，并给予他们多价免疫球蛋白以预防甲型肝炎。在第120天时，1220名受试者身体健康，并再次对他们的血清进行研究。排除其他肝炎病因后，通过粪便中存在病毒或抗甲型肝炎病毒IgM的检测证实，有59例发生了甲型肝炎。在两组中观察到以下结果：a) 在初始血样中甲型肝炎病毒抗体滴度约为1:100的受试者患肝炎的风险降低。滴度较低以及反常地滴度较高的受试者，患肝炎的风险显著更高。b) 未患肝炎的受试者初始血样中乙肝病毒标志物的出现频率较低。c) 在患肝炎的受试者初始样本中，低滴度的甲型肝炎病毒抗体（低于20）通常与乙肝病毒标志物相关。这表明要么对两种病毒感染都存在先天性易感性，要么先前的乙肝病毒感染会增加甲型肝炎病毒感染的风险。
