Monsalve F, Rucabado L, Salvador A, Bonastre J, Cuñat J, Ruano M
Crit Care Med. 1984 Dec;12(12):1021-3. doi: 10.1097/00003246-198412000-00003.
Comparative hemodynamic measurements recorded in 19 cases of septic shock associated with Neisseria meningitidis bacteremia and in 20 shock cases associated with bacteremia due to other Gram-negative bacilli showed a significantly higher incidence of early myocardial depression in the cases with meningococcal infection. Echocardiographic, ECG, and serum enzyme (CK-MB isoenzyme) studies closely correlated with impaired myocardial contractility and development of cardiogenic shock in patients with meningococcal bacteremia. Autopsy of the heart from three patients who succumbed to shock confirmed the presence of myocarditis with intracellular Gram-negative diplococci. Our observations suggest that the onset of cardiac dysfunction precedes clinical manifestations of shock.
对19例伴有脑膜炎奈瑟菌血症的感染性休克患者和20例伴有其他革兰氏阴性杆菌血症的休克患者进行的血流动力学对比测量显示，脑膜炎球菌感染患者早期心肌抑制的发生率显著更高。超声心动图、心电图和血清酶（CK-MB同工酶）研究与脑膜炎球菌血症患者心肌收缩力受损和心源性休克的发展密切相关。对3例死于休克的患者进行的心脏尸检证实存在心肌炎，心肌细胞内有革兰氏阴性双球菌。我们的观察结果表明，心脏功能障碍的发生先于休克的临床表现。
