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本文引用的文献

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Treatment of meningococcal infection.脑膜炎球菌感染的治疗。
Arch Dis Child. 2003 Jul;88(7):608-14. doi: 10.1136/adc.88.7.608.
2
Characterization of a myocardial depressant factor in meningococcal septicemia.脑膜炎球菌败血症中心肌抑制因子的特性
Crit Care Med. 2002 Oct;30(10):2191-8. doi: 10.1097/00003246-200210000-00003.
3
Dysfunction of endothelial protein C activation in severe meningococcal sepsis.严重脑膜炎球菌败血症中内皮细胞蛋白C激活功能障碍。
N Engl J Med. 2001 Aug 9;345(6):408-16. doi: 10.1056/NEJM200108093450603.
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Efficacy and safety of recombinant human activated protein C for severe sepsis.重组人活化蛋白C治疗严重脓毒症的疗效与安全性
N Engl J Med. 2001 Mar 8;344(10):699-709. doi: 10.1056/NEJM200103083441001.
5
Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group.重组杀菌/通透性增加蛋白(rBPI21)作为儿童重症脑膜炎球菌败血症辅助治疗的随机试验。rBPI21脑膜炎球菌败血症研究组。
Lancet. 2000 Sep 16;356(9234):961-7. doi: 10.1016/s0140-6736(00)02712-4.
6
Increased excretion of urinary glycosaminoglycans in meningococcal septicemia and their relationship to proteinuria.脑膜炎球菌败血症患者尿中糖胺聚糖排泄增加及其与蛋白尿的关系。
Crit Care Med. 2000 Aug;28(8):3002-8. doi: 10.1097/00003246-200008000-00054.
7
A myocardial cytotoxic process is involved in the cardiac dysfunction of meningococcal septic shock.脑膜炎球菌性感染性休克所致的心功能障碍涉及心肌细胞毒性过程。
Crit Care Med. 2000 Aug;28(8):2979-83. doi: 10.1097/00003246-200008000-00049.
8
Coagulation system and platelets are fully activated in uncomplicated sepsis.在无并发症的脓毒症中,凝血系统和血小板被完全激活。
Crit Care Med. 2000 Feb;28(2):451-7. doi: 10.1097/00003246-200002000-00027.
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Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.通过基因互补揭示脂多糖与Toll样受体4之间的物理接触。
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Disseminated intravascular coagulation.弥散性血管内凝血
Thromb Haemost. 1999 Aug;82(2):695-705.

脑膜炎球菌性脑膜炎和败血症的病理生理学

Pathophysiology of meningococcal meningitis and septicaemia.

作者信息

Pathan N, Faust S N, Levin M

机构信息

Imperial College of Science, Technology & Medicine, London, UK.

出版信息

Arch Dis Child. 2003 Jul;88(7):601-7. doi: 10.1136/adc.88.7.601.

DOI:10.1136/adc.88.7.601
PMID:12818907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1763171/
Abstract

Neisseria meningitidis is remarkable for the diversity of interactions that the bacterium has with the human host, ranging from asymptomatic nasopharyngeal colonisation affecting virtually all members of the population; through focal infections of the meninges, joints, or eye; to the devastating and often fatal syndrome of meningococcal septic shock and purpura fulminans.

摘要

脑膜炎奈瑟菌与人类宿主的相互作用具有多样性,这一点十分显著。其相互作用范围广泛,从几乎影响所有人群的无症状鼻咽部定植,到脑膜、关节或眼部的局部感染,再到脑膜炎球菌性败血症休克和暴发性紫癜这种极具破坏性且往往致命的综合征。