Curtsinger J W
Genetics. 1984 Dec;108(4):941-52. doi: 10.1093/genetics/108.4.941.
Selection coefficients and segregation parameters have been estimated in 18 randomly chosen lines carrying wild X chromosomes on the cn bw genetic background. Each line was studied in replicated crosses of four types, with approximately 100 replications per line per cross. Crosses in which male X chromosomes differed exhibited significant sex ratio heterogeneity. Maximum likelihood estimation of segregation parameters revealed two lines in which the proportion of X-bearing gametes produced by males was significantly different from Mendelian expectations. These observations suggest that segregation distortion is a common feature of naturally occurring genetic variation. Non-Mendelian segregation has important evolutionary implications.
在携带野生X染色体的cn bw遗传背景下的18条随机选择的品系中，已经估计了选择系数和分离参数。每个品系在四种类型的重复杂交中进行研究，每个品系每个杂交大约有100次重复。雄性X染色体不同的杂交表现出显著的性别比例异质性。分离参数的最大似然估计显示，有两个品系中雄性产生的携带X的配子比例与孟德尔预期有显著差异。这些观察结果表明，分离畸变是自然发生的遗传变异的一个共同特征。非孟德尔分离具有重要的进化意义。
