Bassler M, Just H M, Richter A, Zeller H, Daschner F
Infection. 1984 Jul-Aug;12(4):280-5. doi: 10.1007/BF01645962.
We investigated the antibacterial activity of clindamycin and lincomycin at 1/4 X minimum inhibitory concentration (MIC), 1 X MIC and 4 X MIC against a serum-resistant Staphylococcus aureus and a serum-resistant Staphylococcus epidermidis strain in broth, in serum with and without the presence of leukocytes and in Hank's medium in combination with leukocytes alone. Against both test strains, lincomycin in broth and serum was similarly effective, whereas against S. aureus clindamycin in broth was somewhat more active. In the combined test mixture of serum with leukocytes, even a 1/4 X MIC of clindamycin or lincomycin markedly improved leukocyte killing of S. aureus, whereas both compounds could not further enhance the marked leukocyte killing of S. epidermidis, even at inhibitory concentrations. In Hank's medium with leukocytes alone, clindamycin and lincomycin had at the most only a bacteriostatic effect against both test strains.
我们研究了克林霉素和林可霉素在1/4倍最低抑菌浓度（MIC）、1倍MIC和4倍MIC时，对一株血清抗性金黄色葡萄球菌和一株血清抗性表皮葡萄球菌在肉汤中、有或无白细胞存在的血清中以及仅与白细胞联合的汉克氏培养基中的抗菌活性。对于两种测试菌株，林可霉素在肉汤和血清中的效果相似，而对于金黄色葡萄球菌，克林霉素在肉汤中的活性稍高。在血清与白细胞的联合测试混合物中，即使是1/4倍MIC的克林霉素或林可霉素也能显著提高白细胞对金黄色葡萄球菌的杀伤作用，而即使在抑菌浓度下，这两种化合物也不能进一步增强白细胞对表皮葡萄球菌的显著杀伤作用。在仅含有白细胞的汉克氏培养基中，克林霉素和林可霉素对两种测试菌株最多只有抑菌作用。
