一名儿童慢性髓性白血病的巨核母细胞转化
Megakaryoblastic transformation of chronic myelogenous leukaemia in a child.
作者信息
Hanada T, Nakazawa M, Sakuma H, Takahashi M, Kondo I, Takita H
出版信息
Scand J Haematol. 1984 Nov;33(5):476-81. doi: 10.1111/j.1600-0609.1984.tb00728.x.
Abstract
A child with megakaryoblastic transformation of Ph1-positive chronic myelogenous leukaemia, complicated by myelofibrosis, is reported. The blastic cells were negative for myeloperoxidase by ultrastructural cytochemistry. They had Factor-VIII antigen and platelet glycoprotein but were negative for platelet peroxidase activity. This discrepancy seemed to be due to neoplastic origin of blastic cells.
摘要
报告了1例Ph1阳性慢性粒细胞白血病巨核细胞转化并伴有骨髓纤维化的患儿。超微结构细胞化学显示，原始细胞髓过氧化物酶阴性。它们具有Ⅷ因子抗原和血小板糖蛋白，但血小板过氧化物酶活性阴性。这种差异似乎是由于原始细胞的肿瘤起源所致。
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