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慢性粒细胞白血病的巨核母细胞转化。一项电子显微镜和细胞化学研究。

Megakaryoblastic transformation of chronic granulocytic leukaemia. An electron microscopy and cytochemial study.

作者信息

Bain B, Catovsky D, O'Brien M, Spiers A S, Richards G H

出版信息

J Clin Pathol. 1977 Mar;30(3):235-42. doi: 10.1136/jcp.30.3.235.

DOI:10.1136/jcp.30.3.235
PMID:265307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476365/
Abstract

Morphological, cytochemical, and ultrastructural electron microscopic (EM) studies were performed on blood and bone-marrow cells of case of Ph1-positive chronic ganulocytic leukaemia in megakaryocytic acute transformation. The entire leukaemic cell population was found to consist and of megakaryoblasts and megakaryocytes. Intermediate stages of maturation between blasts and micromegakaryocytes were observed at EM level.

摘要

对1例Ph1阳性慢性粒细胞白血病巨核细胞急性转化患者的血液和骨髓细胞进行了形态学、细胞化学和超微结构电子显微镜（EM）研究。发现整个白血病细胞群体由巨核母细胞和巨核细胞组成。在电子显微镜水平观察到了原始细胞和微小巨核细胞之间的中间成熟阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/5bcf5e40d967/jclinpath00161-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/b6a901216917/jclinpath00161-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/e239b0049233/jclinpath00161-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/b3b34678ee92/jclinpath00161-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/47eb79d5eaa3/jclinpath00161-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/1582ac6bb25f/jclinpath00161-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/8d81f2f12df3/jclinpath00161-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/5bcf5e40d967/jclinpath00161-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/b6a901216917/jclinpath00161-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/e239b0049233/jclinpath00161-0044-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/b3b34678ee92/jclinpath00161-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/47eb79d5eaa3/jclinpath00161-0045-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/1582ac6bb25f/jclinpath00161-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/8d81f2f12df3/jclinpath00161-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1dc/476365/5bcf5e40d967/jclinpath00161-0046-a.jpg

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Chronic megakaryocytic granulocytic myelosis-CMGM. A subtype of chronic myeloid leukemia.

本文引用的文献

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Cytogenetic studies on bone-marrow in chronic myeloid leukaemia.慢性髓细胞白血病骨髓的细胞遗传学研究。
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