Williams W C, Weiss G B
Cancer. 1982 Mar 1;49(5):921-6. doi: 10.1002/1097-0142(19820301)49:5<921::aid-cncr2820490516>3.0.co;2-w.
A 52-year-old man with Ph1-positive chronic myelogenous leukemia (CML) developed a blastic transformation in which the predominant cell type micromegakaryocytes. He did not respond to treatment. A review of the 15 previously reported cases of patients with circulating megakaryocyte abnormalities in association with either CML or a Ph1 chromosome positive myeloproliferative disorder suggests a female predominance rather than the usual male predominance of CML. Survival of the six patients reported as megakaryoblastic transformation of CML as well as this patient was poor.
一名52岁的男性，患有Ph1阳性慢性粒细胞白血病（CML），发生了原始细胞转化，其中主要细胞类型为微巨核细胞。他对治疗无反应。回顾之前报道的15例伴有循环巨核细胞异常的CML或Ph1染色体阳性骨髓增殖性疾病患者的病例，发现女性占优势，而非CML通常的男性占优势。报告为CML巨核母细胞转化的6例患者以及该患者的生存期均较差。
