Isemura M, Munakata H, Kosakai M, Nomoto M, Aoyagi Y, Ichida F, Nagai H, Motomiya M, Yosizawa Z
Tohoku J Exp Med. 1984 Oct;144(2):217-8. doi: 10.1620/tjem.144.217.
Tissue-associated fibronectin was extracted with 4 M urea from human normal and cirrhotic livers. The results of rocket immunoelectrophoresis indicated that the amount of fibronectin in cirrhotic liver was twice as much as that in normal liver. The collagen content was much higher in cirrhotic than in normal livers. These data suggested an important role of fibronectin in tissue fibrosis.
用4M尿素从人正常肝脏和肝硬化肝脏中提取组织相关纤维连接蛋白。火箭免疫电泳结果表明，肝硬化肝脏中纤维连接蛋白的含量是正常肝脏的两倍。肝硬化肝脏中的胶原蛋白含量比正常肝脏高得多。这些数据表明纤维连接蛋白在组织纤维化中起重要作用。
