Laidlaw J L, Connor T H, Theiss J C, Anderson R W, Matney T S
Am J Hosp Pharm. 1984 Dec;41(12):2618-23.
Permeability of latex and polyvinyl chloride (PVC) gloves to 20 injectable antineoplastic drugs was studied. Four types of gloves were evaluated: latex surgical gloves, latex examination gloves, and PVC gloves in two thicknesses. Each glove material was exposed to each drug for 90 minutes, and permeation was tested using a mutagenicity assay. Individual fingertips of thin PVC gloves and latex surgical gloves were tested for permeability at five time points (2-30 minutes) using a doxorubicin coloration assay. All drugs permeated the thin PVC gloves. Latex surgical gloves were definitely permeable to two drugs (carmustine and thiotepa) and exhibited borderline permeability to mechlorethamine hydrochloride. The thick PVC gloves were definitely permeable to four drugs (carmustine, thiotepa, mechlorethamine hydrochloride, and daunorubicin hydrochloride) and exhibited borderline permeability to two drugs (doxorubicin and mercaptopurine). The latex examination gloves were permeable to carmustine, thiotepa, mechlorethamine hydrochloride, and cyclophosphamide. Doxorubicin permeation of individual fingertips of thin PVC gloves varied in time and amount. Doxorubicin did not permeate the latex surgical glove material, but testing with thiotepa showed that individual fingertips of this material also varied in permeability. Glove thickness was a major determinant of permeability; latex surgical gloves were the least permeable and thin PVC gloves the most permeable to the antineoplastic drugs tested. Within individual gloves and glove types, time and amount of permeation were not uniform.
研究了乳胶手套和聚氯乙烯（PVC）手套对20种注射用抗肿瘤药物的渗透性。评估了四种类型的手套：乳胶手术手套、乳胶检查手套以及两种厚度的PVC手套。每种手套材料均与每种药物接触90分钟，并使用致突变性试验检测渗透性。使用阿霉素染色试验在五个时间点（2 - 30分钟）测试薄PVC手套和乳胶手术手套的单个指尖的渗透性。所有药物均能透过薄PVC手套。乳胶手术手套对两种药物（卡莫司汀和噻替派）肯定具有渗透性，对盐酸氮芥表现出临界渗透性。厚PVC手套对四种药物（卡莫司汀、噻替派、盐酸氮芥和盐酸柔红霉素）肯定具有渗透性，对两种药物（阿霉素和巯嘌呤）表现出临界渗透性。乳胶检查手套对卡莫司汀、噻替派、盐酸氮芥和环磷酰胺具有渗透性。薄PVC手套单个指尖的阿霉素渗透情况在时间和量上有所不同。阿霉素未透过乳胶手术手套材料，但用噻替派测试表明该材料的单个指尖在渗透性方面也存在差异。手套厚度是渗透性的主要决定因素；乳胶手术手套对抗肿瘤药物的渗透性最低，薄PVC手套的渗透性最高。在单个手套和手套类型中，渗透的时间和量并不均匀。
