Otto M, Bekemeier H, Hirschelmann R
Biomed Biochim Acta. 1984;43(8-9):S291-5.
The cobra venom factor (CVF) rat paw edema was inhibited by cyclooxygenase (indomethacin, piroxicam, aspirin), lipoxygenase (BW 755c) and thromboxane synthetase (imidazole) inhibitors as well as by dexamethasone and, at high doses, by paracetamol and phenacetin. No definite results were obtained with slow acting antirheumatic drugs (D-penicillamine, levamisole, gold thiosulphate, chloroquine), since results varied considerably. The results are shortly discussed, with respect to the role of arachidonate lipoxygenase products as well as O-radicals.
眼镜蛇毒因子（CVF）所致的大鼠爪肿胀受到环氧化酶抑制剂（吲哚美辛、吡罗昔康、阿司匹林）、脂氧合酶抑制剂（BW 755c）、血栓素合成酶抑制剂（咪唑）以及地塞米松的抑制，高剂量时还受到对乙酰氨基酚和非那西丁的抑制。使用慢作用抗风湿药（D-青霉胺、左旋咪唑、硫代硫酸金、氯喹）未得到明确结果，因为结果差异很大。结合花生四烯酸脂氧合酶产物以及氧自由基的作用对结果进行了简要讨论。
