Pittilo R M, Clarke J M, Harris D, Mackie I J, Rowles P M, Machin S J, Woolf N
Br J Haematol. 1984 Dec;58(4):627-32. doi: 10.1111/j.1365-2141.1984.tb06109.x.
Non-abraded rabbit endothelium has been exposed to human blood taken from male non-smoking volunteers before and after the smoking of two medium tar cigarettes, in an in vitro system using a Baumgartner chamber. In each case the blood was allowed to circulate for 10 min at a constant flow rate. Blood from 10 volunteers has been tested in this way. Scanning electron microscopy of the endothelial surfaces demonstrates large numbers of adherent platelets when 'post-smoking blood' is used, but very few and in some cases none with the 'pre-smoking' blood. As a further control to ensure that this phenomenon did not occur as a result from changes in the vessel related to the time during which it had been removed from its normal physiological environment, blood from further non-smoking volunteers was passed over seven of the remaining pieces of vessel at the completion of these runs. Platelets were either absent or very few in number, as with the pre-smoking samples.
在一个使用鲍姆加特纳腔室的体外系统中，未受损的兔内皮已暴露于从男性不吸烟志愿者身上采集的血液，这些血液分别来自他们吸两支中焦油香烟之前和之后。在每种情况下，血液以恒定流速循环10分钟。用这种方法对来自10名志愿者的血液进行了测试。内皮表面的扫描电子显微镜显示，当使用“吸烟后血液”时，有大量粘附的血小板，但使用“吸烟前血液”时，血小板非常少，在某些情况下甚至没有。作为进一步的对照，以确保这种现象不是由于血管从其正常生理环境中取出后与时间相关的变化而发生的，在这些实验结束时，将来自其他不吸烟志愿者的血液通过剩余七段血管。与吸烟前样本一样，血小板要么不存在，要么数量很少。
