Pittilo R M, Nicholson L J, Clarke J M, Blow C M, Woolf N
Br J Exp Pathol. 1985 Jun;66(3):365-70.
Cultured rat peritoneal mesothelial cells have been exposed to plasma obtained from healthy adult male volunteers before and after the smoking of two medium-tar cigarettes. The pre-smoking plasma had little effect on the mesothelial cells as observed by scanning electron microscopy. Post-smoking plasma produced extensive cellular damage evidenced by the production of blebs and microvillus-like structures on the cell surface. Some cells were also found to have a perforated luminal membrane. These results suggest that factors cytotoxic for these cells are present in plasma following exposure of humans to cigarette smoke.
培养的大鼠腹膜间皮细胞被暴露于健康成年男性志愿者在吸食两支中焦油香烟前后采集的血浆中。通过扫描电子显微镜观察发现，吸烟前的血浆对间皮细胞几乎没有影响。吸烟后的血浆导致了广泛的细胞损伤，表现为细胞表面出现泡状突起和微绒毛样结构。还发现一些细胞的管腔膜有穿孔。这些结果表明，人类接触香烟烟雾后，血浆中存在对这些细胞具有细胞毒性的因子。
