Makarov P R, Zinchenko V P, Shartava A Sh, Sakson M E, Evtodienko Iu V
Biofizika. 1984 Nov-Dec;29(6):1006-9.
Ionophore A23187 induces three-phase kinetics of reduction of chlorotetracycline (CTC) lauded lymphocyte fluorescence: fast reduction, low increase and lower reduction of fluorescence. We suggested the following explanation of kinetics. The first phase is extinguishing of the Ca2+ - CTC complex fluorescence induced by ionophore A23187 perturbation of the cell membrane, the second one is the energy dependent Ca2+ entry into the cell and the third one is the slow efflux of Ca2+ ions from the cell to concentration gradient.
离子载体A23187诱导淋巴细胞中氯四环素（CTC）荧光还原呈现三相动力学：快速还原、荧光微弱增加以及更低程度的荧光还原。我们对该动力学提出了如下解释。第一阶段是离子载体A23187对细胞膜的扰动引发的Ca2+ - CTC复合物荧光熄灭，第二阶段是能量依赖的Ca2+进入细胞，第三阶段是Ca2+离子顺着浓度梯度缓慢流出细胞。
