Sánchez J, Bastien C, Medrano G, Riquet M, Derenne J P
Bull Eur Physiopathol Respir. 1984 Nov-Dec;20(6):535-40.
The activities of hexokinase (HK), lactate dehydrogenase (LDH), citrate synthase (CS) and 3-hydroxyacyl-CoA-dehydrogenase (HAD) were measured in the costal diaphragm (DI) and in the latissimus dorsi (LD), a non respiratory muscle, of 21 middle aged men: 10 normal subjects and 11 patients with moderate chronic obstructive pulmonary disease (COPD). In the normal subjects, all the enzymatic activities were significantly higher in the diaphragm (p less than 0.01) than in the latissimus dorsi, the mean increase ranging from 61 to 118%. Chronic obstructive pulmonary disease failed to cause any further increase in enzymatic activities in the DI; on the contrary, a significant decrease of HK and LDH (30%, p less than 0.01) was observed. Enzymatic activities of LD were unaffected by COPD. These data show that the metabolic enzymatic activities in the diaphragm of normal middle aged subjects is similar to that of the vastus lateralis of highly trained young athletes, suggesting that DI is a highly trained muscle in normal man.
对21名中年男性的肋膈肌（DI）和背阔肌（LD，一种非呼吸肌）进行了己糖激酶（HK）、乳酸脱氢酶（LDH）、柠檬酸合酶（CS）和3-羟酰基辅酶A脱氢酶（HAD）活性的测定，其中包括10名正常受试者和11名中度慢性阻塞性肺疾病（COPD）患者。在正常受试者中，膈肌的所有酶活性均显著高于背阔肌（p<0.01），平均增幅在61%至118%之间。慢性阻塞性肺疾病未能使膈肌的酶活性进一步增加；相反，观察到HK和LDH显著降低（30%，p<0.01）。背阔肌的酶活性不受COPD影响。这些数据表明，正常中年受试者膈肌的代谢酶活性与训练有素的年轻运动员的股外侧肌相似，提示膈肌在正常男性中是一块训练有素的肌肉。
