Kosaka K, Aoki M, Kawasaki N, Adachi Y, Konuma I, Iizuka R
Clin Neuropathol. 1984 Nov-Dec;3(6):231-6.
In Japan Wernicke's encephalopathy is not rare, but only one case of Marchiafava-Bignami disease has been reported. In our case, Wernicke lesions were found in the mamillary bodies, septal nuclei, and periventricular regions. Involvement of the septal nuclei is rare in this encephalopathy. A characteristic Marchiafava-Bignami lesion was observed only in the anterior part of the corpus callosum. From the clinicopathologic viewpoint, Wernicke's encephalopathy might have preceded Marchiafava-Bignami disease in our case. To our knowledge, only two cases without a history of alcoholism and both suffering from Wernicke's encephalopathy and Marchiafava-Bignami disease have been documented. However, in both cases Wernicke lesions were atypical, since characteristic lesions were absent in the mamillary bodies and in the regions surrounding the third ventricle and the aqueduct. Ours appears to be the first report on a non-alcoholic patient with typical lesions of both diseases.
在日本，韦尼克脑病并不罕见，但马尔恰法瓦-比尼亚米病仅报告过一例。在我们的病例中，在乳头体、隔核和脑室周围区域发现了韦尼克病变。隔核受累在这种脑病中较为罕见。仅在胼胝体前部观察到典型的马尔恰法瓦-比尼亚米病变。从临床病理学角度来看，在我们的病例中，韦尼克脑病可能先于马尔恰法瓦-比尼亚米病出现。据我们所知，仅有两例无酗酒史且同时患有韦尼克脑病和马尔恰法瓦-比尼亚米病的病例被记录在案。然而，在这两例中，韦尼克病变均不典型，因为乳头体以及第三脑室和导水管周围区域均未出现典型病变。我们的病例似乎是首例关于一名非酒精性患者同时患有这两种疾病典型病变的报告。
