Artico M, Corelli F, Massa S, Stefancich G, Panico S, Simonetti N
Farmaco Sci. 1984 Nov;39(11):910-24.
A new analog of nalidixic acid, 1-ethyl-1,4-dihydro-4-oxo--7-(1-pyrryl)quinoline-3-carboxylic acid, is described. When tested against gram-positive and gram-negative bacteria this compound showed many significant activities and was more active than nalidixic, piromidic and pipemidic acids. On the contrary its 6-chloro- and 6-methylderivatives lack antimicrobial activities. All new compounds here described were synthesized by standard procedures via Gould-Jacobs reaction.
描述了一种新的萘啶酸类似物，即1-乙基-1,4-二氢-4-氧代-7-(1-吡咯基)喹啉-3-羧酸。当针对革兰氏阳性菌和革兰氏阴性菌进行测试时，该化合物表现出许多显著的活性，并且比萘啶酸、吡咯米酸和哌酸更具活性。相反，其6-氯代和6-甲基衍生物缺乏抗菌活性。本文所述的所有新化合物均通过标准程序经由古尔德-雅各布斯反应合成。
