吡咯菌素类似物。XI——新型1,4-和1,5-二芳基吡咯的合成及微生物活性
Pyrrolnitrin analogues. XI--Synthesis and microbiological activity of new 1,4- and 1,5-diarylpyrroles.
作者信息
Porretta G C, Chimenti F, Biava M, Bolasco A, Scalzo M, Panico S, Simonetti N, Villa A
出版信息
Farmaco Sci. 1985 Aug;40(8):589-607.
PMID:4043377
Abstract
The synthesis and microbiological activities of new 1,4- and 1,5-diarylpyrroles is reported. Antimicrobial data in comparison with fungal antibiotic pyrrolnitrin confirm an interesting antimicotic activity of 1,4-diarylpyrroles. On the contrary 1,5-diarylpyrroles show antibacterial activity and an unexpected antimicotic activity. The position of the 4-nitrophenyl group at C4 or C5 of the pyrrole ring influences antibacterial activity.
摘要
报道了新型1,4 - 和1,5 - 二芳基吡咯的合成及其微生物活性。与真菌抗生素硝吡咯菌素相比的抗菌数据证实了1,4 - 二芳基吡咯具有有趣的抗真菌活性。相反，1,5 - 二芳基吡咯表现出抗菌活性和意外的抗真菌活性。吡咯环C4或C5位上4 - 硝基苯基的位置影响抗菌活性。
Zotero 插件