Schoeman J F, Elyas A A, Brett E M, Lascelles P T
Dev Med Child Neurol. 1984 Dec;26(6):749-55. doi: 10.1111/j.1469-8749.1984.tb08168.x.
A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy. Children stabilised on standard doses of CBZ alone showed a ratio of CBZ-10,11-EPOX/CBZ of 18.92 +/- 8.08, expressed as a percentage of the CBZ concentration, while those on multiple-drug therapy (with the exception of benzodiazepines and phenobarbitone) showed both increased values of CBZ-10,11-EPOX/CBZ ratio and increased absolute concentrations of CBZ-10,11-EPOX in plasma. These changes correlated with clinical side-effects which could not be attributed to CBZ itself or to the other drugs administered concurrently.
一种测量卡马西平 - 10,11 - 环氧化物（CBZ - 10,11 - EPOX）的方法已被开发出来，并用于监测患有各种形式癫痫的儿童的血浆浓度。仅使用标准剂量卡马西平稳定病情的儿童，其CBZ - 10,11 - EPOX/CBZ比值（以CBZ浓度的百分比表示）为18.92±8.08，而接受多药治疗（苯二氮卓类和苯巴比妥除外）的儿童，其CBZ - 10,11 - EPOX/CBZ比值升高，且血浆中CBZ - 10,11 - EPOX的绝对浓度也升高。这些变化与临床副作用相关，而这些副作用不能归因于卡马西平本身或同时使用的其他药物。
