仅服用卡马西平以及与其他抗惊厥药联合服用的癫痫患者体内卡马西平10, 11环氧化物的浓度。
Carbamazepine 10, 11 epoxide concentrations in epileptics on carbamazepine alone and in combination with other anticonvulsants.
作者信息
Brodie M J, Forrest G, Rapeport W G
出版信息
Br J Clin Pharmacol. 1983 Dec;16(6):747-9. doi: 10.1111/j.1365-2125.1983.tb02257.x.
Abstract
Steady state carbamazepine (CBZ) plasma concentrations were similar in 15 epileptics receiving monotherapy and in 24 patients taking CBZ in combination with one other anticonvulsant. The ratio of CBZ 10, 11-epoxide (CBZ-E) to the parent drug was significantly higher (P less than 0.01) in those patients taking concomitant phenytoin (n = 9), phenobarbitone or primidone (n = 9), and valproic acid (n = 6) than in the patients receiving CBZ alone. In the monotherapy group, there was a significant correlation between CBZ-E/CBZ ratio and the concentration of the parent drug (P less than 0.05). If CBZ-E has equipotent anticonvulsant properties to CBZ in man as is the case in animal models, routine CBZ-E concentrations may provide further refinement in the therapeutic drug monitoring of CBZ.
摘要
15 名接受单一疗法的癫痫患者以及 24 名同时服用卡马西平（CBZ）和另一种抗惊厥药物的患者，其稳态卡马西平血浆浓度相似。在同时服用苯妥英（n = 9）、苯巴比妥或扑米酮（n = 9）以及丙戊酸（n = 6）的患者中，CBZ 10, 11 - 环氧化物（CBZ - E）与母体药物的比率显著高于（P < 0.01）仅接受 CBZ 治疗的患者。在单一疗法组中，CBZ - E/CBZ 比率与母体药物浓度之间存在显著相关性（P < 0.05）。如果在人体中 CBZ - E 与 CBZ 具有同等的抗惊厥特性，如同在动物模型中那样，那么常规的 CBZ - E 浓度可能会在 CBZ 的治疗药物监测中提供进一步的优化。
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