Bhattacharyya S N, Bell D Y
Inflammation. 1984 Dec;8(4):407-15. doi: 10.1007/BF00918216.
Two glycoproteins of Mr 62,000 and 36,000 have been isolated and purified from lung lavage of normal human and patients with sarcoidosis and bibasilar fibrosis. The two glycoproteins contained hydroxyproline, high amounts of glycine, and other amino acids in amounts comparable to those present in the same two glycoproteins isolated from lung lavage of patients with alveolar proteinosis. The antibody raised against the glycoprotein of Mr 36,000 isolated from lung lavage material of patients with alveolar proteinosis reacted with both the glycoproteins isolated from normal human as well as from patients with sarcoidosis and bibasilar fibrosis, indicating that these glycoproteins isolated from different sources are structurally related to each other.
已从正常人、结节病患者和双基底纤维化患者的肺灌洗物中分离并纯化出两种分子量分别为62,000和36,000的糖蛋白。这两种糖蛋白含有羟脯氨酸、大量甘氨酸以及其他氨基酸，其含量与从肺泡蛋白沉积症患者肺灌洗物中分离出的相同两种糖蛋白中的含量相当。针对从肺泡蛋白沉积症患者肺灌洗物中分离出的分子量为36,000的糖蛋白产生的抗体，与从正常人以及结节病和双基底纤维化患者中分离出的这两种糖蛋白均发生反应，表明从不同来源分离出的这些糖蛋白在结构上彼此相关。
