Characterization of two glycoproteins isolated from lung lavage fluid of normal human and from patients with two pulmonary diseases.

Two glycoproteins of Mr 62,000 and 36,000 have been isolated and purified from lung lavage of normal human and patients with sarcoidosis and bibasilar fibrosis. The two glycoproteins contained hydroxyproline, high amounts of glycine, and other amino acids in amounts comparable to those present in the same two glycoproteins isolated from lung lavage of patients with alveolar proteinosis. The antibody raised against the glycoprotein of Mr 36,000 isolated from lung lavage material of patients with alveolar proteinosis reacted with both the glycoproteins isolated from normal human as well as from patients with sarcoidosis and bibasilar fibrosis, indicating that these glycoproteins isolated from different sources are structurally related to each other.