Sahu S, Lynn W S
Inflammation. 1979 Sep;3(4):437-45. doi: 10.1007/BF00913501.
A new glycoprotein with an apparent molecular weight of 130,000 was isolated, purified, and partially characterized from the pulmonary secretions which accumulate so massively in the lungs of patients suffering from pulmonary alveolar proteinosis. The amino acid analysis of the glycoprotein showed the presence of relatively high amounts of glycine, glutamic acid, aspartic acid, leucine, and valine, and small amounts of hydroxyproline, but no hydroxylysine. It contains approximately 6% hexose, 3% sialic acid, and 4% glucosamine. The neutral sugars are galactose, mannose, and fucose. This alveolar glycoprotein cross-reacted with an antiserum prepared in rabbits against a larger glycoprotein (250,000 mol wt) isolated from the same source, suggesting that the larger alveolar glycoprotein may be the precursor of the smaller one.
从肺泡蛋白沉积症患者肺部大量积聚的肺分泌物中分离、纯化并部分鉴定出一种表观分子量为130,000的新糖蛋白。该糖蛋白的氨基酸分析表明，其中甘氨酸、谷氨酸、天冬氨酸、亮氨酸和缬氨酸含量相对较高，羟脯氨酸含量较少，但不含羟赖氨酸。它含有约6%的己糖、3%的唾液酸和4%的葡糖胺。中性糖为半乳糖、甘露糖和岩藻糖。这种肺泡糖蛋白与用兔制备的针对从同一来源分离的较大糖蛋白（分子量250,000）的抗血清发生交叉反应，表明较大的肺泡糖蛋白可能是较小糖蛋白的前体。
