Moriyama Y, Koike T, Shibata A
Jpn J Clin Oncol. 1984 Dec;14 Suppl 1:531-6.
The situation regarding hemorrhagic cystitis after conditioning for bone marrow transplantation (BMT) in Japan was surveyed and analyzed. Thirty-seven of 110 patients (33.6%) developed hemorrhagic cystitis after conditioning for BMT with cyclophosphamide (CY) and total body irradiation. In two of these 37 patients the cystitis was virus (adenovirus)-induced. In the others it was diagnosed as CY-induced. The severity and duration of CY-induced hemorrhagic cystitis were related to its onset. The delayed type of hemorrhagic cystitis induced by CY seemed to have a poor prognosis and often continued until the patient died. Therefore, late-onset hemorrhagic cystitis should be followed carefully and its prophylaxis may be important. 2-Mercaptoethane sulphonate (mesna) injections for prophylaxis of CY-induced hemorrhagic cystitis were found to be effective in reducing the incidence of the delayed type in 21 (53.8%) of 39 patients treated, but did not reduce the total incidence of CY-induced hemorrhagic cystitis.
我们对日本骨髓移植（BMT）预处理后出血性膀胱炎的情况进行了调查和分析。110例患者中，有37例（33.6%）在接受环磷酰胺（CY）和全身照射进行BMT预处理后发生了出血性膀胱炎。在这37例患者中，有2例膀胱炎是由病毒（腺病毒）引起的。其他患者则被诊断为CY诱导性膀胱炎。CY诱导性出血性膀胱炎的严重程度和持续时间与发病情况有关。CY诱导的迟发性出血性膀胱炎预后似乎较差，常常持续到患者死亡。因此，对于迟发性出血性膀胱炎应密切观察，其预防可能很重要。在39例接受治疗的患者中，有21例（53.8%）接受2-巯基乙烷磺酸盐（美司钠）注射预防CY诱导性出血性膀胱炎，结果发现美司钠可有效降低迟发性出血性膀胱炎的发生率，但并未降低CY诱导性出血性膀胱炎的总发生率。
