Cooper M D, Jeffery C, Dever C A
Scan Electron Microsc. 1984(Pt 4):1925-30.
Organ cultures of human fallopian tube were used to assess the potential role of gonococcal IgA1 protease in infection of mucosal tissue. A genetically cloned IgA1 protease deficient mutant and its wild type parent were used to infect fallopian tube organ cultures. The comparative rate and extent of attachment, invasion and damage to the organ cultures by the gonococcal mutant and its parent type were assessed by scanning and transmission electron microscopy and determined to be indistinguishable from one another. These results indicate that the lack of IgA1 protease does not compromise the gonococcus in its ability to infect previously uninfected human fallopian tube mucosa.
利用人输卵管器官培养物来评估淋球菌IgA1蛋白酶在粘膜组织感染中的潜在作用。使用基因克隆的IgA1蛋白酶缺陷型突变体及其野生型亲本感染输卵管器官培养物。通过扫描电子显微镜和透射电子显微镜评估淋球菌突变体及其亲本型对器官培养物的附着、侵袭和损伤的相对速率和程度，结果确定两者没有区别。这些结果表明，缺乏IgA1蛋白酶并不损害淋球菌感染先前未感染的人输卵管粘膜的能力。
