Vinje O, Førre O, Degre M, Møller P
Scand J Rheumatol. 1984;13(4):297-302. doi: 10.3109/03009748409111299.
Sixteen patients with Bechterew's syndrome (ankylosing spondylitis, AS) were investigated. All except one of the patients were HLA B27-positive. Peripheral blood lymphocytes from the patients were examined for spontaneous cytotoxicity against 51Cr-labelled K562 target cells. The cytotoxicity index of the non-T lymphocytes was negatively correlated with the serum CRP concentration (Pearson's r = 0.613, p less than 0.02). This finding seems to be caused by an alteration of the natural killer (NK) cell activity of the non-T lymphocytes during the active phase of the disease and not due to serum factors. The activity of the non-T cell fraction was slightly but not significantly reduced in patients with high disease activity (CRP greater than 0.01 g/l) compared with normal controls, (14.6 +/- 2.8 g/l versus 20.4 +/- 2.4 g/l mean +/- SE; p less than 0.10) Serum IgG and IgA concentrations were increased (p less than 0.001 and p less than 0.05 respectively) Interferon caused normal augmentation in the NK cell activity in AS patients, and no correlation was found between serum gamma interferon titres and the NK cell activity.
对16例贝赫切特综合征（强直性脊柱炎，AS）患者进行了研究。除1例患者外，其余所有患者HLA B27均呈阳性。检测了患者外周血淋巴细胞对51Cr标记的K562靶细胞的自发细胞毒性。非T淋巴细胞的细胞毒性指数与血清CRP浓度呈负相关（Pearson相关系数r = 0.613，p < 0.02）。这一发现似乎是由疾病活动期非T淋巴细胞的自然杀伤（NK）细胞活性改变引起的，而非血清因素所致。与正常对照组相比，疾病活动度高（CRP > 0.01 g/l）的患者非T细胞部分的活性略有降低，但差异无统计学意义（分别为14.6 ± 2.8 g/l和20.4 ± 2.4 g/l，均值 ± 标准误；p < 0.10）。血清IgG和IgA浓度升高（分别为p < 0.001和p < 0.05）。干扰素使AS患者的NK细胞活性正常增强，且血清γ干扰素滴度与NK细胞活性之间未发现相关性。
