Dillon J R, Pauzé M
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):353-9.
The development of gonococcal resistance to antimicrobial agents, attributable to either chromosomal mutation or to the acquisition of plasmid-mediated penicillin resistance, has been a significant trend of the past several decades. Decreased susceptibility of Neisseria gonorrhoeae to therapeutically effective antibiotics, such as spectinomycin and some cephalosporins, has also been reported. Thus, the monitoring of antimicrobial susceptibility is critical to determine whether particular treatment regimens will be effective in a given geographic area. The association between auxotype and susceptibility to antimicrobial agents has often been overlooked as a rationale for changes in susceptibility patterns. For example, the dramatic increase in the prevalence of the Pro-,Cit-,Ura- auxotype in Canada since 1973 has been associated with an increase in penicillin-resistant isolates. The association between auxotype and plasmid carriage may also indirectly play a role in resistance of N. gonorrhoeae to antibiotics. Finally, the possibility that new plasmid-determined resistances may be acquired by N. gonorrhoeae from species of Haemophilus is reviewed.
淋球菌对抗菌药物产生耐药性，这归因于染色体突变或获得质粒介导的青霉素耐药性，这是过去几十年的一个显著趋势。也有报道称，淋病奈瑟菌对治疗有效的抗生素（如壮观霉素和一些头孢菌素）的敏感性降低。因此，监测抗菌药物敏感性对于确定特定治疗方案在特定地理区域是否有效至关重要。作为敏感性模式变化的一个理由，菌型与抗菌药物敏感性之间的关联常常被忽视。例如，自1973年以来，加拿大Pro-、Cit-、Ura-菌型的流行率急剧上升，这与青霉素耐药菌株的增加有关。菌型与质粒携带之间的关联也可能间接在淋病奈瑟菌对抗生素的耐药性中起作用。最后，综述了淋病奈瑟菌可能从嗜血杆菌属物种获得新的质粒介导耐药性的可能性。
