Dillon J R, Pauzé M, Yeung K H
Genitourin Med. 1986 Jun;62(3):151-7. doi: 10.1136/sti.62.3.151.
Though the number of penicillinase producing Neisseria gonorrhoeae (PPNG) strains isolated in Canada comprises under 1% of all gonococcal isolates, it continues to increase appreciably each year. Most strains are imported from areas of endemic infection with PPNG strains. Two local outbreaks in 1984, however, were notable for the number of patients infected and for the distinctive phenotypes of the strains. One outbreak was caused by a wild type strain, of serovar BACJK with a new 3.05 megadalton penicillinase encoding plasmid, whereas the other was caused by strains with the Asia+ plasmid type, serovar AE and with a proline and ornithine requiring auxotype. Five plasmid patterns (Africa+, Africa-, Asia+, Asia-, and Toronto+) were observed among the PPNG strains. The association between plasmid content and specific auxotype (such as Asia plasmid with proline requiring auxotype or Africa plasmid with wild type auxotype) and inhibition by phenylalanine continues to be unexplained.
尽管在加拿大分离出的产青霉素酶淋病奈瑟菌（PPNG）菌株数量占所有淋球菌分离株的比例不到1%，但其每年仍在显著增加。大多数菌株是从PPNG菌株的地方性感染地区输入的。然而，1984年的两次本地暴发因感染患者数量以及菌株独特的表型而引人注目。一次暴发是由一株野生型菌株引起的，该菌株属于血清型BACJK，带有一个新的编码3.05兆道尔顿青霉素酶的质粒，而另一次暴发是由具有Asia+质粒类型、血清型AE且为脯氨酸和鸟氨酸需求型营养缺陷型的菌株引起的。在PPNG菌株中观察到了五种质粒模式（Africa+、Africa-、Asia+、Asia-和Toronto+）。质粒含量与特定营养缺陷型（如具有脯氨酸需求型营养缺陷型的Asia质粒或具有野生型营养缺陷型的Africa质粒）之间的关联以及苯丙氨酸的抑制作用仍无法解释。
