口服甲砜霉素和口服赖甲环素治疗产青霉素酶淋病奈瑟菌感染
Treatment of infection due to penicillinase-producing Neisseria gonorrhoeae with oral thiamphenicol and with oral lymecycline.
作者信息
Latif A S, Marowa E, Mason P R, Sithole J, Tambo J, Dhamu F, Paraiwa E
出版信息
Sex Transm Dis. 1986 Jul-Sep;13(3):156-8. doi: 10.1097/00007435-198607000-00008.
Seventy-five men with gonococcal urethritis were treated with a single oral dose of thiamphenicol, and 88 men with this infection were treated with two 1.5-g oral doses of lymecycline taken 12 hr apart. Of the 75 subjects treated with thiamphenicol, 72 (96%) were cured, as compared with 80 (91%) treated with lymecycline. Sixty subjects (37%) were infected with penicillinase-producing Neisseria gonorrhoeae. In this group, 28 (97%) of 29 subjects treated with thiamphenicol were cured, as compared with 29 (94%) of 31 subjects treated with lymecycline. Patient compliance with the two-dose regimen was excellent, and no adverse effects occurred with either drug. Lymecycline may therefore be an effective alternative to thiamphenicol in those countries where strains of N. gonorrhoeae remain sensitive to the tetracyclines.
75例淋菌性尿道炎男性患者接受了单剂量口服甲砜霉素治疗，88例该感染男性患者接受了间隔12小时分两次口服1.5g赖甲环素的治疗。在接受甲砜霉素治疗的75名受试者中，72例（96%）治愈，相比之下，接受赖甲环素治疗的80例（91%）治愈。60名受试者（37%）感染了产青霉素酶的淋病奈瑟菌。在这一组中，接受甲砜霉素治疗的29名受试者中有28例（97%）治愈，相比之下，接受赖甲环素治疗的31名受试者中有29例（94%）治愈。患者对两剂疗法的依从性良好，两种药物均未出现不良反应。因此，在淋病奈瑟菌菌株对四环素仍敏感的国家，赖甲环素可能是甲砜霉素的一种有效替代药物。
Zotero 插件