Santos C
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):401-3.
In an eight-year study of thiamphenicol, 4,500 male patients with previously untreated, acute, uncomplicated gonococcal urethritis were selected for treatment with this drug. Gonococcal urethritis was diagnosed in all instances by microscopic examination of gram-stained urethral smears. In ambiguous cases, specimens were cultured on modified Thayer-Martin medium. All patients initially received a single oral dose of 2.5 g of thiamphenicol. This regimen resulted in clinical recovery within 24-48 hr in 4,028 patients (89.5%). The remaining 472 patients received a second regimen consisting of a single intramuscular injection of 750 mg of thiamphenicol followed 6 hr later by a single oral dose of 2.5 g; 462 (98%) of these patients recovered. Altogether, the two regimens produced a recovery rate of 99.8%. The drug was well tolerated both gastrointestinally and hematologically; blood tests performed for 2,000 patients showed no hematologic changes.
在一项为期八年的甲砜霉素研究中，选取了4500名先前未经治疗的急性单纯性淋菌性尿道炎男性患者使用该药进行治疗。所有病例均通过革兰氏染色尿道涂片的显微镜检查诊断为淋菌性尿道炎。在不明确的病例中，标本在改良的Thayer-Martin培养基上培养。所有患者最初均接受单次口服2.5克甲砜霉素。该治疗方案使4028名患者（89.5%）在24至48小时内临床康复。其余472名患者接受了第二种治疗方案，即单次肌内注射750毫克甲砜霉素，6小时后再单次口服2.5克；其中462名患者（98%）康复。总体而言，两种治疗方案的康复率为99.8%。该药在胃肠道和血液方面耐受性良好；对2000名患者进行的血液检查未显示血液学变化。
