[Chromosome aberrations in F1 (NZBxNZW) mice--an experimental model of systemic lupus erythematosus].
作者信息
Skazkina O Ia, Lil'p I G, Pleskovskaia G N, Tugolukova S S, Korogodina Iu V
出版信息
Tsitol Genet. 1984 Nov-Dec;18(6):458-9.
PMID:6441320
Abstract
Spontaneous and mitomycin-C-induced chromosomal aberration level was studied in bone marrow cells of mice F1 (NZBXNZW), an experimental model of systemic lupus erythematosus and in C57BL/6J mice. The chromosome instability level is found to correspond to the degree of the autoimmune process: F1 (NZBXNZW) mice with the highest titer of autoantibodies to DNA has higher chromosomal mutability.
摘要
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