Emerit I, Michelson A M
Acta Physiol Scand Suppl. 1980;492:59-65.
Increased chromosome breakage is observed in lymphocyte cultures from patients with so-called autoimmune diseases also in the animal model, the NZB mouse. A clastogenic agent was detected in the serum of patients and of NZB mice, that induces also chromosome breaks in cells of healthy individuals. In simultaneous cultures set up with or without superoxide dismutase in 5 patients with progressive systemic sclerosis, 5 patients with systemic lupus erythematosus and 5 patients with rheumatoid arthritis, highly significant differences in the incidence of chromosome breakage were observed. The aberration rate produced in blood cultures of healthy individuals by the breakage factor from patients was also reduced essentially to control values by addition of SOD in vitro, but were reduced also in vivo by injection of SOD in lupus patients as well as in NZB mice.
在所谓的自身免疫性疾病患者的淋巴细胞培养物中以及动物模型新西兰黑鼠（NZB小鼠）中，都观察到染色体断裂增加。在患者和NZB小鼠的血清中检测到一种致断裂剂，它也会诱导健康个体细胞中的染色体断裂。在用或不用超氧化物歧化酶（SOD）建立的同步培养物中，对5例进行性系统性硬化症患者、5例系统性红斑狼疮患者和5例类风湿关节炎患者进行研究，观察到染色体断裂发生率存在高度显著差异。通过体外添加SOD，患者的断裂因子在健康个体血液培养物中产生的畸变率基本降低到对照值，而且在狼疮患者以及NZB小鼠体内注射SOD后，畸变率也有所降低。
