Kenward M A, Alcock S R, McKay I C
Antimicrob Agents Chemother. 1984 Dec;26(6):833-6. doi: 10.1128/AAC.26.6.833.
Modern diving techniques can require the treatment of infection in an atmosphere of pressurized oxyhelium gas. The antibiotic susceptibility of 16 species and strains (eight genera) of gram-negative bacilli and 3 species and strains (two genera) of gram-positive cocci to each of 21 antimicrobial agents was assessed in air at atmospheric pressure and in oxyhelium gas at an absolute pressure of 7 bar (ca. 709 kPa). A disk diffusion technique was employed, and significantly different results were obtained in the two atmospheres. The effect of oxyhelium on diameters of growth inhibition varied significantly with the bacterium and with the antibiotic and was particularly marked with certain bacterium-antibiotic combinations. The gram-negative bacilli generally gave reduced zone diameters in oxyhelium, whereas the gram-positive cocci showed a mixture of effects.
现代潜水技术可能需要在加压的氧氦气体环境中治疗感染。评估了16种革兰氏阴性杆菌（8个属）和3种革兰氏阳性球菌（2个属）对21种抗菌剂在常压空气中以及在绝对压力为7巴（约709千帕）的氧氦气体中的抗生素敏感性。采用纸片扩散法，在两种环境中获得了显著不同的结果。氧氦对生长抑制直径的影响因细菌和抗生素而异，在某些细菌 - 抗生素组合中尤为明显。革兰氏阴性杆菌在氧氦环境中通常抑菌圈直径减小，而革兰氏阳性球菌则表现出多种不同的效应。
