Marquis R E, Thom S R, Crookshank C A
Undersea Biomed Res. 1978 Jun;5(2):189-98.
Helium at pressures of 20 to 70 atm in the presence of air found to stimulate growth of Streptococcus faecalis, Escherichia coli, and Staphylococcus aureus, mainly by increasing the rate of exponential growth. However, at these same pressures, helium potentiated the growth-inhibitory actions of oxygen and nitrous oxide (N2O). Oxygen was found to act essentially as an anesthetic gas in inhibiting growth of S. faecalis; its potency was approximately the same as that of N2O, and it acted additively in combination with N2O to inhibit the streptococcus. Oxygen proved to be more potent than N2O in inhibiting the growth of E. coli and S. aureus, and each gas potentiated the action of the other. Oxygen sensitivity was correlated with N2O sensitivity. Overall, our findings indicate that bacterial growth inhibition by anesthetic gases does not accurately reflect narcotic action.
在20至70个大气压下，在有空气存在的情况下，发现氦气主要通过提高指数生长速率来刺激粪肠球菌、大肠杆菌和金黄色葡萄球菌的生长。然而，在相同压力下，氦气增强了氧气和一氧化二氮（N2O）的生长抑制作用。发现氧气在抑制粪肠球菌生长方面基本上起到麻醉气体的作用；其效力与N2O大致相同，并且它与N2O联合作用时可累加抑制链球菌。事实证明，氧气在抑制大肠杆菌和金黄色葡萄球菌生长方面比N2O更有效，并且每种气体都增强了另一种气体的作用。氧气敏感性与N2O敏感性相关。总体而言，我们的研究结果表明，麻醉气体对细菌生长的抑制并不能准确反映麻醉作用。
