Veksler I G, Riabukha V N, Smelkova M I, Balitskiĭ K P
Eksp Onkol. 1984;6(6):50-3.
Different pharmacologic drugs (isadrin, obsidan, phentolamine) changing adrenergic processes are shown to have different effect on the growth and development of lung metastases. An increase in the antimetastatic effect of some cytostatics is also observed in mice with Lewis carcinoma and melanoma B-16 under the influence of isadrin, a stimulator of beta-adrenoreceptors. In authors' opinion, isadrin changes microcirculation in lungs and prevents inhibition of the immune reactivity in animals with metastatic tumours, thus contributing to inhibition of the development and growth of metastases.
不同的改变肾上腺素能过程的药物（异他林、奥昔丹、酚妥拉明）对肺转移瘤的生长和发展有不同影响。在Lewis癌和B-16黑色素瘤小鼠中，在β-肾上腺素能受体刺激剂异他林的影响下，还观察到一些细胞抑制剂的抗转移作用增强。作者认为，异他林改变肺部微循环，防止转移性肿瘤动物的免疫反应性受到抑制，从而有助于抑制转移瘤的发展和生长。
