Syromiatnikov A V, Alistratov A V, Balitskiĭ K P
Eksp Onkol. 1990;12(2):62-6.
Different combinations and doses of neurotropic drugs of the central action (spasmolytine, midantane, L-DOPA) coupled with the surgical removal of the lung Lewis carcinoma were studied for their effect on the metastatic spreading in C57BL/6 mice. It has been established that the long-term use of spasmolytine and midantane before and after the operation inhibits the metastatic process, that is expressed in the total volume reduction of lung metastases, lack of metastases in a number of mice and augmentation of the average life. Such method of drug application is more effective in the metastatic growth inhibition as against their application only in the pre- or postoperation periods as well as with the use of the other neurotropic drug combinations.
研究了中枢作用的神经营养药物（解痉素、金刚烷胺、左旋多巴）的不同组合和剂量与Lewis肺癌手术切除相结合对C57BL/6小鼠转移扩散的影响。已确定，术前和术后长期使用解痉素和金刚烷胺可抑制转移过程，表现为肺转移总体积减少、部分小鼠无转移以及平均寿命延长。与仅在术前或术后使用这些药物以及使用其他神经营养药物组合相比，这种给药方法在抑制转移生长方面更有效。
