Veksler I G, Riabukha V N, Chubinskaia S G, Shvarts G Ia
Biull Eksp Biol Med. 1987 Jul;104(7):79-81.
In experiments on C57 Bl mice the effects of growth and metastatic proliferation of Lewis lung carcinoma inoculated intramuscularly on metabolism and kinin activity have been studied during the application of pharmacologic agents (parmidin, cellulose sulphate, unithiol). Causing a weak inhibition of the primary tumour growth, parmidin if administered repeatedly in given doses, inhibits partially metastatic process, which is manifested in an essential decrease of the quantity, size and weight of lung metastases. Parmidin also inhibits an adverse effect of cellulose sulphate and unithiol on metastatic process. It is believed that the action of parmidin is of an indirect character and is mainly associated with the elimination of the kinin component of microcirculatory disorders in the lungs.
在对C57 Bl小鼠进行的实验中，研究了肌肉注射接种的Lewis肺癌的生长和转移增殖对代谢和激肽活性的影响，实验期间使用了药物制剂（帕米定、硫酸纤维素、二巯基丙醇）。帕米定对原发性肿瘤生长有微弱抑制作用，如果按给定剂量反复给药，可部分抑制转移过程，表现为肺转移灶的数量、大小和重量显著减少。帕米定还可抑制硫酸纤维素和二巯基丙醇对转移过程的不良影响。据信，帕米定的作用具有间接性质，主要与消除肺部微循环障碍中的激肽成分有关。
