Lindahl J, Werner B, Lerner R
Eur J Clin Invest. 1984 Dec;14(6):431-4. doi: 10.1111/j.1365-2362.1984.tb01208.x.
To investigate the origin of the cyclic changes in the rate of endogenous carbon-monoxide production (nCO) during the menstrual cycle, haem turnover was determined before and after chorion gonadotropic hormone-induced ovulation in six female rabbits. 14C-labelled delta-aminolevulinic acid and glycine were administered and the excretion rate of 14CO (A14CO) was measured for determination of hepatic and bone-marrow haem turnover, respectively. Carbon-monoxide production (nCO) was measured to estimate total haem turnover. After ovulation A14CO was increased significantly the first 2 h of the early labelled peak after 14C-ALA administration and was increased also at the first determination during the early peak after 14C-glycine but statistically not significantly. The total excretion of labelled CO during the period of the early labelled peak was not increased with any of these precursors for haem synthesis. On the other hand nCO was increased 34% (P less than 0.05) during the post-ovulation period. As the increase in 'unassigned' haem turnover was small and may be unaccompanied by a contemporary increase in bilirubin/CO production, it was concluded that the increase in nCO during the post-ovulation period essentially depends on increased destruction of circulating red cells in the rabbit.
为研究月经周期中内源性一氧化碳生成速率（nCO）周期性变化的起源，对6只雌兔在绒毛膜促性腺激素诱导排卵前后测定了血红素周转率。分别给予14C标记的δ-氨基乙酰丙酸和甘氨酸，并测定14CO（A14CO）的排泄率，以分别测定肝脏和骨髓的血红素周转率。测量一氧化碳生成量（nCO）以估算总血红素周转率。排卵后，在给予14C-ALA后的早期标记峰的前2小时，A14CO显著增加，在给予14C-甘氨酸后的早期峰的首次测定时也增加，但无统计学意义。在早期标记峰期间，这些血红素合成前体中的任何一种都未使标记CO的总排泄量增加。另一方面，排卵后nCO增加了34%（P<0.05）。由于“未分配”的血红素周转率增加较小，且可能未伴随胆红素/CO生成的同时增加，因此得出结论，排卵后nCO的增加主要取决于兔循环红细胞破坏的增加。
