Watanabe H
Neuropharmacology. 1984 Nov;23(11):1335-8. doi: 10.1016/0028-3908(84)90055-8.
We investigated effects of immobilization stress and haloperidol on levodopa accumulation in caudate, mesolimbic area and frontal cortex of rats treated with an amino acid decarboxylase inhibitor. Immobilization stress for 35 min significantly increased levodopa accumulation in mesolimbic area but not in caudate and frontal cortex, although haloperidol (0.2 mg/kg, i.p., 60 min) enhanced levodopa accumulation in three brain regions. These results suggest that immobilization stress selectively accelerates dopamine synthesis in mesolimbic dopamine neurons.
我们研究了制动应激和氟哌啶醇对用氨基酸脱羧酶抑制剂处理的大鼠尾状核、中脑边缘区和额叶皮质中左旋多巴蓄积的影响。35分钟的制动应激显著增加了中脑边缘区的左旋多巴蓄积，但尾状核和额叶皮质中未增加，尽管氟哌啶醇（0.2mg/kg，腹腔注射，60分钟）增强了三个脑区的左旋多巴蓄积。这些结果表明，制动应激选择性地加速了中脑边缘多巴胺能神经元中的多巴胺合成。
